When is the right moment?
The start of a period, always. A tax year is cleanest; a VAT quarter is nearly as good. Switching mid-period means one set of figures lives in two places, and the reconciliation at the end is worse than the migration you were trying to avoid.
The forcing deadline for most people is Making Tax Digital. Once your income brings you into scope, quarterly updates have to be filed from compatible software, and a spreadsheet on its own no longer clears the bar. The thresholds and start dates have been phased and rephased, so check gov.uk for where you actually sit rather than working from something you read a year ago.
The other honest trigger is simpler: when you no longer trust the sheet. A formula that broke in March and was noticed in September is not a tooling preference, it is a filed return based on numbers nobody can vouch for.